Giant Cell Tumor of Bone in Patients under 16 Years Old: A Single-Institution Case Series

Background: Giant cell tumor of bone is a locally aggressive, rarely metastasizing that accounts for about 5% tumors and generally occurs in patients between 20 45 years old. A driver mutation the histone 3.3 (H3.3) gene H3F3A has been identified as many 96% giant bone. The immunohistochemical expression H3.3 G34 was found 97.8% cases. In present study, we describe our series cases pediatric <16 Methods: All old treated institute 1982 2018 were reviewed. Immunohistochemistry and/or molecular analysis mutations performed to confirm diagnosis. group aneurysmal cysts used control group. Results: Fifteen retrieved. pronounced female predominance (93%) observed. pure metaphyseal central location 2 skeletally immature patients. Conclusions: should be distinguished from its mimickers due differences prognosis treatment. Immunohistochemical detection represents reliable diagnostic tool.